Published References

Death from Lyme/MSIDS infections in the heart​

Increasing Burden of Lyme Carditis in United States Children’s Hospitals.
Beach CM, Hart SA, Nowalk A, Feingold B, Kurland K, Arora G.
Pediatr Cardiol. 2019 Nov 14. doi: 10.1007/s00246-019-02250-9.[Epub ahead of print]
PMID: 31728570
Powassan virus encephalitis, severe babesiosis and lyme carditis in a single patient.
Khan AM, Shahzad SR, Ashraf MF, Naseer U.
BMJ Case Rep. 2019 Nov 10;12(11). pii: e231645. doi: 10.1136/bcr-2019-231645.
PMID: 31712240
Lyme Carditis: A Rare Presentation of Sinus Bradycardia Without Any Conduction Defects.
Grella BA, Patel M, Tadepalli S, Bader CW, Kronhaus K.
Cureus. 2019 Sep 2;11(9):e5554. doi: 10.7759/cureus.5554.
PMID: 31695976
Fatal Lyme Carditis in New England: Two Case Reports.
Marx GE, Leikauskas J, Lindstrom K, Mann E, Reagan-Steiner S, Matkovic E, Read JS, Kelso P, Kwit NA, Hinckley AF, Levine MA, Brown C.
Ann Intern Med. 2019 Oct 22. doi: 10.7326/L19-0483. [Epub ahead of print] No abstract available.
PMID: 31634915
Risk factors for Lyme carditis: A case-control study.
Marcos LA, Castle PM, Smith K, Khoo T, Morley EJ, Bloom M, Fries BC.
Eur J Prev Cardiol. 2019 Sep 19:2047487319876046. doi: 10.1177/2047487319876046. [Epub ahead of print] No abstract available.
PMID: 31537125
Lyme Carditis.
Rivera OJ, Nookala V.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.2019 Aug 19.
PMID: 31536195
Incidence and Prevalence of Borrelia burgdorferi Antibodies in Male Professional Football Players.
Breitbart P, Meister S, Meyer T, Gärtner BC.
Clin J Sport Med. 2019 May 30. doi: 10.1097/JSM.0000000000000758. [Epub ahead of print]
PMID: 31241490
Lyme carditis atrioventricular block: management strategies.
Crinion D, Yeung C, Baranchuk A.
Europace. 2019 Jun 5. pii: euz051. doi: 10.1093/europace/euz051. [Epub ahead of print] No abstract available.
PMID: 31168586
Lyme carditis atrioventricular block: management strategies-Authors’ reply.
Isath A, Padmanabhan D, Naksuk N, Kella D, Friedman P.
Europace. 2019 Jun 5. pii: euz111. doi: 10.1093/europace/euz111. [Epub ahead of print] No abstract available.
PMID: 31168567
Lyme carditis presenting as atrial fibrillation in a healthy young male.
Shabbir MA, Saad Shaukat MH, Arshad MH, Sacco J.
BMJ Case Rep. 2019 Jun 4;12(6). pii: e229261. doi: 10.1136/bcr-2019-229261.
PMID: 31167768
First case report of inducible heart block in Lyme disease and an update of Lyme carditis.
Kannangara DW, Sidra S, Pritiben P.
BMC Infect Dis. 2019 May 16;19(1):428. doi: 10.1186/s12879-019-4025-0.
PMID: 31096922
Lyme carditis presenting as atrial fibrillation.
Zainal A, Hanafi A, Nadkarni N, Mubasher M, Lingutla D, Hoefen R.
BMJ Case Rep. 2019 Apr 29;12(4). pii: e228975. doi: 10.1136/bcr-2018-228975.
PMID: 31036741
A small intergenic region of lp17 is required for evasion of adaptive immunity and induction of pathology by the Lyme disease spirochete.
Casselli T, Crowley MA, Highland MA, Tourand Y, Bankhead T.
Cell Microbiol. 2019 Jul;21(7):e13029.doi:10.1111/cmi.13029. Epub 2019 Apr 16.
PMID: 30945408
Borrelia burgdorferi bbk13 Is Critical for Spirochete Population Expansion in the Skin during Early Infection.
Aranjuez GF, Kuhn HW, Adams PP, Jewett MW.
Infect Immun. 2019 Apr 23;87(5). pii: e00887-18. doi:10.1128/IAI.00887-18. Print 2019 Mar.
PMID: 30782856
Diagnosis and Treatment of Lyme Carditis: JACC Review Topic of the Week.
Yeung C, Baranchuk A.
J Am Coll Cardiol. 2019 Feb 19;73(6):717-726. doi:10.1016/j.jacc.2018.11.035. Review.
PMID: 30765038
Lyme Disease-An Unusual Cause of a Mitral Valve Endocarditis.
Fatima B, Sohail MR, Schaff HV.
Mayo Clin Proc Innov Qual Outcomes. 2018 Oct 25;2(4):398-401. doi: 10.1016/j.mayocpiqo.2018.09.003. eCollection 2018 Dec.
PMID: 30560244
A tick beat in the electrocardiogram: Persistent third degree block as only manifestation of Lyme disease.
Jiménez-Castillo RA, Carrizales-Sepúlveda EF, Vera-Pineda R, Herrera-Elizondo JL, García-Sarreón A, Reyes-Mondragón AL, Mercado-Domínguez E, Marfil-Rivera LJ.
J Electrocardiol. 2019 Jan – Feb;52:109-111. doi: 10.1016/j.jelectrocard.2018.12.005. Epub 2018 Dec 6.
PMID: 30551061
Letter to the editor on “Suspicious Index in Lyme Carditis (SILC): Systematic review and proposed new risk score”.
Shoar S, Naderan M, Shoar N.
Clin Cardiol. 2018 Dec;41(12):1617-1618. doi: 10.1002/clc.23122. Epub 2018 Dec 5. No abstract available.
PMID: 30467884
Suspicious index in Lyme carditis: Construction of a new risk model in the absence of guidelines.
Baranchuk A, Yeung C.
Clin Cardiol. 2018 Dec;41(12):1619. doi: 10.1002/clc.23121. Epub 2018 Dec 5. No abstract available.
PMID: 30467874
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O.
Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):201-208. doi: 10.1007/s10096-018-3417-1. Epub 2018 Nov 19. Review.
PMID: 30456435

Lyme disease can cause Psychiatric Illness and suicide:

Proposed Lyme Disease Guidelines and Psychiatric Illnesses.
Bransfield RC, Cook MJ, Bransfield DR.
Healthcare (Basel). 2019 Sep 9;7(3). pii: E105. doi: 10.3390/healthcare7030105. Review.
PMID: 31505800
Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice.
Bransfield RC.
Healthcare (Basel). 2018 Aug 25;6(3). pii: E104. doi: 10.3390/healthcare6030104. Review.
PMID: 30149626
Aggressiveness, violence, homicidality, homicide, and Lyme disease.
Bransfield RC.
Neuropsychiatr Dis Treat. 2018 Mar 9;14:693-713. doi: 10.2147/NDT.S155143. eCollection 2018.
PMID: 29576731
Suicide and Lyme & associated diseases.
Bransfield RC.
Neuropsychiatr Dis Treat. 2017 Jun 16;13:1575-1587. doi: 10.2147/NDT.S136137. eCollection 2017.
PMID: 28670127
Divergent opinions of proper Lyme disease diagnosis and implications for children co-morbid with autism spectrum disorder.
Kuhn M, Bransfield R.
Med Hypotheses. 2014 Sep;83(3):321-5.doi:10.1016/j.mehy. 2014.06.005. Epub 2014 Jun 16.
PMID: 24986703
Autism and Lyme disease.
Bransfield RC, Kuhn M.
JAMA. 2013 Aug 28;310(8):856-7. doi: 10.1001/jama.2013.194747. No abstract available.
PMID: 23982378
The psychoimmunology of lyme/tick-borne diseases and its association with neuropsychiatric symptoms.
Bransfield RC.
Open Neurol J. 2012;6:88-93. doi: 10.2174/1874205X01206010088. Epub 2012 Oct 5.
PMID: 23091569
Long term antibiotic therapy may be an effective treatment for children co-morbid with Lyme disease and autism spectrum disorder.
Kuhn M, Grave S, Bransfield R, Harris S.
Med Hypotheses. 2012 May;78(5):606-15. doi: 10.1016/j.mehy.2012.01.037. Epub 2012 Feb 22.
PMID: 22361005
Augmenting the impact of technology adoption with financial incentive to improve radiology report signature times.
Andriole KP, Prevedello LM, Dufault A, Pezeshk P, Bransfield R, Hanson R, Doubilet PM, Seltzer SE, Khorasani R.
J Am Coll Radiol. 2010 Mar;7(3):198-204. doi: 10.1016/j.jacr.2009.11.011.
PMID: 20193925
Morgellons disease, illuminating an undefined illness: a case series.
Harvey WT, Bransfield RC, Mercer DE, Wright AJ, Ricchi RM, Leitao MM.
J Med Case Rep. 2009 Jul 1;3:8243. doi: 10.4076/1752-1947-3-8243.
PMID: 19830222
The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders.
Bransfield RC, Wulfman JS, Harvey WT, Usman AI.
Med Hypotheses. 2008;70(5):967-74. Epub 2007 Nov 5.
PMID: 17980971
Treatment of patients with persistent symptoms and a history of Lyme disease.
Bransfield R, Brand S, Sherr V.
N Engl J Med. 2001 Nov 8;345(19):1424-5. No abstract available.
PMID: 11794179
Diagnosis, treatment, & prevention of Lyme disease.
Bransfield RC.
JAMA. 1998 Sep 23-30;280(12):1049; author reply 1051. No abstract available.
PMID: 9757842
The diagnosis of Lyme disease.
Bransfield RC.
Hosp Pract (1995). 1996 Aug 15;31(8):35, 40. No abstract available.
PMID: 9119928
Late-stage neuropsychiatric Lyme borreliosis. Differential diagnosis and treatment.
Fallon BA, Schwartzberg M, Bransfield R, Zimmerman B, Scotti A, Weber CA, Liebowitz MR.
Psychosomatics. 1995 May-Jun;36(3):295-300. No abstract available.
PMID: 7638317
Bransfield RC.
Psychosomatics. 1987 Jul;28(7):344-5. No abstract available.
PMID: 3438451

Birth Defects associated with Lyme/MSIDS

A systematic review was conducted to summarise the global literature on adverse birth outcomes associated with gestational Lyme disease in humans.

Adverse birth outcomes included spontaneous miscarriage or fatal death (n=12), newborn death (n=8), and newborns with abnormal outcome (e.g. hyperbilirubinemia, respiratory distress and syndactyly) at birth (N=16).